Abstract-Design and application of terahertz metamaterial sensor based on DSRRs in clinical quantitative detection of carcinoembryonic antigen

Ning Cui, Min Guan, Mengke Xu, Weihao Fang, Yang Zhang, Chenfeng Zhao, and Yiping Zeng

(a) Schematic diagram of THz MMs biosensor chip; (b) Detection principle and the equivalent circuit for the DSRRs. (The capacitance of substrates and sample are expressed as 𝐶sub$C\text{sub}$ and 𝐶sam$C\text{sam}$, respectively. 𝐿𝑠$Ls$ is expressed as inductance of DSRRs.)

https://www.osapublishing.org/oe/abstract.cfm?uri=oe-28-11-16834

The terahertz (THz) metamaterial biosensor has great potential for label-free and rapid specificity testing. Here, we designed two highly sensitive structures to detect the carcinoembryonic antigen (CEA) of the cancer biomarker in early stages. There was about 29 GHz (500 ng/ml) resonance shift for CEA with an insert grate metamaterial, which was consistent with simulation results. Moreover, the concentration of CEA was gained through the relationship between the cancer marker concentration and frequency shift (Δƒ). Our design and detection methods may provide a potential route for the early warning stages of cancer.

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