Abstract-Study of protein conformation change induced by pH condition using terahertz spectroscopy

Jun Zhou, Xin Rao, Junhong Tian,  Jiafu Wang, Tao Li,

https://ieeexplore.ieee.org/document/8068501/

The terahertz absorption spectra of BSA (Bovine Serum Albumin) in aqueous solution were measured under different pH values from 2.2 to 8. The absorption spectra were analyzed using the two-dimensional correlation spectroscopy (2DCOS). By comparing the cross peaks corresponding to the different pH values, it can be obtained that the conformation is related to the pH condition.