Showing posts with label Junliang Dong. Show all posts
Showing posts with label Junliang Dong. Show all posts

Wednesday, April 1, 2020

Abstract-Terahertz three-dimensional monitoring of nanoparticle-assisted laser tissue soldering


Junliang Dong, Holger Breitenborn, Riccardo Piccoli, Lucas V. Besteiro, Pei You, Diego Caraffini, Zhiming M. Wang, Alexander O. Govorov, Rafik Naccache, Fiorenzo Vetrone, Luca Razzari, and Roberto Morandotti

Schematic showing the range of simultaneous photothermal reactions during nanoparticle-assisted laser tissue soldering.

https://www.osapublishing.org/boe/abstract.cfm?uri=boe-11-4-2254

In view of minimally-invasive clinical interventions, laser tissue soldering assisted by plasmonic nanoparticles is emerging as an appealing concept in surgical medicine, holding the promise of surgeries without sutures. Rigorous monitoring of the plasmonically-heated solder and the underlying tissue is crucial for optimizing the soldering bonding strength and minimizing the photothermal damage. To this end, we propose a non-invasive, non-contact, and non-ionizing modality for monitoring nanoparticle-assisted laser-tissue interaction and visualizing the localized photothermal damage, by taking advantage of the unique sensitivity of terahertz radiation to the hydration level of biological tissue. We demonstrate that terahertz radiation can be employed as a versatile tool to reveal the thermally-affected evolution in tissue, and to quantitatively characterize the photothermal damage induced by nanoparticle-assisted laser tissue soldering in three dimensions. Our approach can be easily extended and applied across a broad range of clinical applications involving laser-tissue interaction, such as laser ablation and photothermal therapies.
© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Wednesday, December 18, 2019

Turning light energy into heat to fight disease





WASHINGTON, D.C., December 17, 2019 -- An emerging technology involving tiny particles that absorb light and turn it into localized heat sources shows great promise in several fields, including medicine. For example, photothermal therapy, a new type of cancer treatment, involves aiming infrared laser light onto nanoparticles near the treatment site.
Localized heating in these systems must be carefully controlled since living tissue is delicate. Serious burns and tissue damage can result if unwanted heating occurs in the wrong place. The ability to monitor temperature increases is crucial in developing this technology. Several approaches have been tried, but all of them have drawbacks of various kinds, including the need to insert probes or inject additional materials.
In this week's issue of APL Photonics, from AIP Publishing, scientists report the development of a new method to measure temperatures in these systems using a form of light known as terahertz radiation. The study involved suspensions of gold nanorods of various sizes in water in small cuvettes, which were illuminated by a laser focused on a small spot within the cuvette.
The tiny gold rods absorbed the laser light and converted it to heat that spread through the water by convection. "We are able to map out the temperature distribution by scanning the cuvette with terahertz radiation, producing a thermal image," co-author Junliang Dong said.
The study also looked at the way the temperature varied over time. "Using a mathematical model, we are able to calculate the efficiency by which the gold nanorod suspensions converted infrared light to heat," said co-author Holger Breitenborn.
The smallest gold particles, which had a diameter of 10 nanometers, converted laser light to heat with the highest efficiency, approximately 90%. This value is similar to previous reports for these gold particles, indicating the measurements using terahertz radiation were accurate.
Although the smaller gold rods had the highest light-to-heat conversion efficiency, the largest rods -- those with a diameter of 50 nanometers -- displayed the largest molar heating rate. This quantity has been recently introduced to help evaluate the use of nanoparticles in biomedical settings.
"By combining measurements of temperature transients in time and thermal images in space at terahertz frequencies, we have developed a noncontact and noninvasive technique for characterizing these nanoparticles," co-author Roberto Morandotti said. This work offers an appealing alternative to invasive methods and holds promise for biomedical applications.
###
The article, "Quantifying the photothermal conversion efficiency of plasmonic nanoparticles by means of terahertz radiation," is authored by H. Breitenborn, J. Dong, R. Piccoli, A. Bruhacs, L.V. Besteiro, A. Skripka, Z. Wang, A.O. Govorov, L. Razzari, F. Vetrone, R. Naccache and R. Morandotti. The article will appear in the journal APL Photonics on Dec. 17, 2019 (DOI: 10.1063/1.5128524). After that date, it can be accessed at https://aip.scitation.org/doi/10.1063/1.5128524.

Sunday, July 15, 2018

Abstract-Visualization of subsurface damage in woven carbon fiber-reinforced composites using polarization-sensitive terahertz imaging



Junliang Dong, Pascal Pomarède, Lynda Chehami, Alexandre Locquet, Fodil Meraghni, Nico F.Declercq, D.S.Citrin,

https://www.sciencedirect.com/science/article/pii/S0963869518301610


    Polarization-sensitive terahertz imaging is applied to characterize subsurface damage in woven carbon fiber-reinforced composite laminates in this study. Terahertz subsurface spectral imaging based on terahertz deconvolution is tailored and applied to detect, in a nondestructive fashion, the subsurface damage within the first ply of the laminate caused by a four-point bending test. Subsurface damage types, including matrix cracking, fiber distortion/fracture, as well as intra-ply delamination, are successfully characterized. Our results show that, although the conductivity of carbon fibers rapidly attenuates terahertz propagation with depth, the imaging capability of terahertz radiation on woven carbon fiber-reinforced composites can nonetheless be significantly enhanced by taking advantage of the terahertz polarization and terahertz deconvolution. The method demonstrated in this study is capable of extracting and visualizing a number of fine details of the subsurface damage in woven carbon fiber-reinforced composites, and the results achieved are confirmed by comparative studies with X-ray tomography.

    Saturday, December 16, 2017

    Abstract-Terahertz Quantitative Nondestructive Evaluation of Failure Modes in Polymer-Coated Steel



    Junliang Dong,   Alexandre Locquet,   D. S. Citrin,

    http://ieeexplore.ieee.org/document/7572023/


    Terahertz reflective imaging is applied to characterize the failure modes in a polymer coating on a steel plate. The coating was initially scratched, then after accelerated aging, several types of failure have occurred. In order to resolve the thin coating (~50 μm), terahertz frequency-wavelet domain deconvolution is implemented. With the deconvolved signals, the temporally overlapping echoes of the incident, roughly single-cycle terahertz pulse are clearly resolved, and three important failure modes, viz. corrosion, delamination, and blistering, are characterized quantitatively. Terahertz images in three dimensions clearly exhibit the coating thickness distribution across the entire damaged coating, highlighting the terahertz features associated with different failure modes, thus demonstrating that terahertz imaging can be considered as an effective modality for characterizing damage mechanisms in polymer coatings on metals.

    Friday, December 1, 2017

    Imaging Technique Unlocks the Secrets of 17th Century Artists



    Credit: Georgia Tech Photo: John Toon
    Georgia Tech professor David Citrin is shown with images produced by a terahertz imaging technique. Researchers studied a 17th century painting using a terahertz reflectometry technique to analyze individual paint layers.

    http://www.newswise.com/articles/imaging-technique-unlocks-the-secrets-of-17th-century-artists



    Newswise — The secrets of 17th century artists can now be revealed, thanks to 21st century signal processing. Using modern high-speed scanners and the advanced signal processing techniques, researchers at the Georgia Institute of Technology are peering through layers of pigment to see how painters prepared their canvasses, applied undercoats, and built up layer upon layer of paint to produce their masterpieces.
    The images they produce using the terahertz scanners and the processing technique – which was mainly developed for petroleum exploration – provide an unprecedented look at how artists did their work three centuries ago. The level of detail produced by this terahertz reflectometry technique could help art conservators spot previous restorations of paintings, highlight potential damage – and assist in authenticating the old works.
    Beyond old art, the nondestructive technique also has potential applications for detecting skin cancer, ensuring proper adhesion of turbine blade coatings and measuring the thickness of automotive paints. The study was reported November 8 in the journal Scientific Reports.
    “This technique allows us to see at high resolution what is beneath the surface of a painting, to assess in depth what kind of technique has been used, and to determine what defects may be present,” said Alexandre Locquet, an adjunct professor in Georgia Tech’s School of Electrical and Computer Engineering and a researcher at the Georgia Tech-CNRS international laboratory in Metz, France. “Using this, we can get information that art historians previously did not have, and we can provide information that may be helpful to the conservation and restoration of these old paintings.”
    The researchers studied the painting “Madonna in Preghiera” by the workshop of Giovanni Battista Salvi da Sassoferrato, which was on loan from the Musée de la Cour d’Or, Metz Métropole, France. The examination began by placing the artwork face down on a gantry device designed to support the canvas without sagging.
    Using a commercial terahertz scanner, the painting was then examined approximately every 200 microns by pulses of terahertz radiation. The scanner consists of an electromagnetic wave generator, which emits signals that penetrated through successive layers of the painting. Portions of the beam reflected back from the paint, producing signals from each layer as the scanner moved across the painting in a raster pattern similar to that used to create television images.
    A computer using a signal processing technique known as sparsity-based time-domain deconvolution then processed the data, separating the signals reflected by each layer to construct a three-dimensional map of the image. The canvas support, ground, imprimatura, underpainting, pictorial and varnish layers were identified, along with a previously unknown restoration of the varnish.
    “Our technique is similar to the way in which seismology can be used to identify the various layers of rock in the ground,” said David Citrin, a professor in the Georgia Tech School of Electrical and Computer Engineering. “In that case, seismologists send in an acoustic pulse and then measure the resulting echoes. In a similar way, we use a pulse of electromagnetic radiation at a frequency of around one terahertz and then look at the reflections off the various layers, a science known as stratigraphy.”
    Without the signal processing, researchers might only be able to identify layers 100 to 150 microns thick. But using the advanced processing, they can distinguish layers just 20 microns thick. Paintings done before the 18th century have been challenging to study because their paint layers tend to be thin, Citrin said. Individual pigments cannot be resolved by the technique, though the researchers hope to be able to obtain that information in the future.
    “This is really quite significant, because for years people have tried to use raw data, but you really can’t see much in that without processing the signals,” he said. “It takes coupling the terahertz signals with the signal processing to really make a difference.”
    Terahertz radiation, also known as submillimeter radiation, operates at tremendously high frequencies. It can easily penetrate layers of paint, though it can be blocked by conductive pigments such as carbon black. The terahertz imaging technique can supplement conventional art analysis techniques such as X-rays, nuclear magnetic resonance imaging, and optical imaging.
    The research team, which included graduate student Junliang Dong and collaborator Marcello Melis, has also studied other paintings, and plans to image a small part of a 12th century wood panel painting. That work will be challenging because the paint is thin and the wood surface damaged.
    Citrin believes the study is the first to detect individual paint layers in a pre-18th century work of art.
    “Different techniques provide different information that could be useful to art conservators and historians,” he said. “Terahertz gives us the combined ability to image a large object relatively quickly and inexpensively. We have shown that you don’t need a fancy system to extract useful information.”
    Beyond paintings, Citrin’s research group has also imaged a Byzantine coin through a thick layer of oxidation, and is attempting to read an inscription in a medieval lead funerary cross also obscured by an oxide layer. They are also collaborating with a research group in Hong Kong to use the technique for characterizing the layers of skin for skin cancer detection and with another group for measuring damage in composite materials.
    “Terahertz imaging is still an emerging field that has to find its best applications,” said Locquet. “We are hoping to contribute to that, and are pleased to apply science and engineering to support the humanities.”
    CITATION: Junliang Dong, Alexandre Locquet, Marcello Melis & D. S. Citrin, “Global mapping of stratigraphy of an old-master painting using sparsity-based terahertz reflectometry,” (Scientific Reports, 2017) http://dx.doi.org/10.1038/s41598-017-15069-2

    Tuesday, May 9, 2017

    Abstract-Terahertz Superresolution Stratigraphic Characterization of Multilayered Structures Using Sparse Deconvolution


    Junliang Dong,  Xiaolong Wu,  Alexandre Locquet, David S. Citrin,

    http://ieeexplore.ieee.org/document/7874211/

    Terahertz sparse deconvolution based on an iterative shrinkage algorithm is presented in this study to characterize multilayered structures. With an upsampling approach, sparse deconvolution with superresolution is developed to overcome the time resolution limited by the sampling period in the measurement and increase the precision of the estimation of echo arrival times. A simple but effective time-domain model for describing the temporal pulse spreading due to the frequency-dependent loss is also designed and introduced into the algorithm, which greatly improves the performance of sparse deconvolution in processing time-varying pulses during the propagation of terahertz waves in materials. Numerical simulations and experimental measurements verify the algorithms and show that sparse deconvolution can be considered as an effective tool for terahertz nondestructive characterization of multilayered structures.

    Saturday, May 6, 2017

    Abstract-Depth resolution enhancement of terahertz deconvolution by autoregressive spectral extrapolation


    Junliang Dong, Alexandre Locquet, and D. S. Citrin

    https://www.osapublishing.org/ol/abstract.cfm?uri=ol-42-9-1828&origin=search

    This Letter presents a method for enhancing the depth resolution of terahertz deconvolution based on autoregressive (AR) spectral extrapolation. The terahertz frequency components with a high signal-to-noise ratio (SNR) are modeled with an AR process, and the missing frequency components in the regions with low SNRs are extrapolated based on the AR model. In this way, the entire terahertz frequency spectrum of the impulse response function, corresponding to the material structure, is recovered. This method, which is verified numerically and experimentally, is able to provide a “quasi-ideal” impulse response function and, therefore, greatly enhances the depth resolution for characterizing optically thin layers in the terahertz regime.
    © 2017 Optical Society of America

    Saturday, November 12, 2016

    Abstract-Terahertz frequency-wavelet domain deconvolution for stratigraphic and subsurface investigation of art painting



    Junliang Dong, J. Bianca Jackson, Marcello Melis, David Giovanacci, Gillian C. Walker, Alexandre Locquet, John W. Bowen, and D. S. Citrin

    https://www.osapublishing.org/oe/abstract.cfm?uri=oe-24-23-26972

    Terahertz frequency-wavelet deconvolution is utilized specifically for the stratigraphic and subsurface investigation of art paintings with terahertz reflective imaging. In order to resolve the optically thin paint layers, a deconvolution technique is enhanced by the combination of frequency-domain filtering and stationary wavelet shrinkage, and applied to investigate a mid-20th century Italian oil painting on paperboard, After Fishing, by Ausonio Tanda. Based on the deconvolved terahertz data, the stratigraphy of the painting including the paint layers is reconstructed and subsurface features are clearly revealed, demonstrating that terahertz frequency-wavelet deconvolution can be an effective tool to characterize stratified systems with optically thin layers.
    © 2016 Optical Society of America
    Full Article  |  PDF Article