Pengfei Wang, Liyuan Liu, Xiangchao Wang, Jianbing Zhang, Wei Qi, Hongwei Zhao, Zhen Tian, Mingxia He
https://www.sciencedirect.com/science/article/abs/pii/S0301010419300035
A silicon-based sensor, consisting of periodical split ring resonators was demonstrated to monitor monomeric and dimeric insulin solutions in terahertz time-domain spectroscopy (THz-TDS). As concentration increases, the resonant frequencies of sensor show red shifts with a rapid trend in dilute solutions and a slow trend in concentrated solutions, consistent with CST simulations. For monomeric insulin, the turning concentration is 11.6mg/ml and the total frequency shift is larger than that of dimeric insulin which shows a turning concentration at 17.4mg/ml. The deviation in frequency shift and turning concentration can be attributed to the structural changes of insulin during dimerization process.
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