[-] Author Affiliationshttp://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1887716
Kun Meng
China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, China
China Academy of Engineering Physics, Terahertz Research Center, Mianyang, Sichuan 621900, China
Tu-nan Chen
China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, China
Third Military Medical University, Southwest Hospital, Department of Neurosurgery, No. 30, Gaotanyan Street, Shapingba, Chongqing 400038, China
Tao Chen, Jian-heng Zhao
China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, China
Li-guo Zhu, Qiao Liu, Sen-cheng Zhong, Ze-ren Li
China Academy of Engineering Physics, Institute of Fluid Physics, Interdisciplinary Laboratory of Physics and Biomedicine, No. 64, Mianshan Road, Mianyang, Sichuan 621900, China
China Academy of Engineering Physics, Terahertz Research Center, Mianyang, Sichuan 621900, China
Zhao Li, Fei Li, Hua Feng
Third Military Medical University, Southwest Hospital, Department of Neurosurgery, No. 30, Gaotanyan Street, Shapingba, Chongqing 400038, China
J. Biomed. Opt. 19(7), 077001 (Jul 07, 2014). doi:10.1117/1.JBO.19.7.077001
History: Received April 11, 2014; Revised June 4, 2014; Accepted June 13, 2014
Open Access
Abstract. The refractive indices, absorption coefficients, and complex dielectric constants of paraffin-embedded brain glioma and normal brain tissues have been measured by a terahertz time-domain spectroscopy (THz-TDS) system in the 0.2- to 2.0-THz range. The spectral differences between gliomas and normal brain tissues were obtained. Compared with normal brain tissue, our results indicate that paraffin-embedded brain gliomas have a higher refractive index, absorption coefficient, and dielectric constant. Based on these results, the best THz frequencies for different methods of paraffin-embedded brain glioma imaging, such as intensity imaging, coherent imaging with continuum THz sources, and THz pulsed imaging with short-pulsed THz sources, are analyzed.
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