Los Alamos, NM--A team of researchers led by Los Alamos National Laboratory has evaluated the cellular response of mouse stem cells exposed to terahertz (THz) radiation. Low-power radiation was applied from a pulsed broadband (centered at 10 THz) source and from a CW CO2 laser (2.52 THz) source. The researchers determined that temperature increases were minimal, and that heat shock protein expression was unaffected--while the expression of certain other genes showed clear effects of the THz irradiation.
Terahertz technologies are increasingly finding applications in medicine, military, security, and research, including cancer detection, airport security, shipment inspection, and spectroscopy. However, relatively little is known about the effect of THz radiation on biological systems. Earlier studies are referenced in the journal article and in the THz-BRIDGE project, pulished in 2004.
The researchers work is described in the September issue of the open-access journal Biomedical Optics Express, published by the Optical Society of America. The findings indicate that mouse mesenchymal stem cells exposed to THz radiation exhibit specific changes in cellular function closely related to the gene expression. Further investigations involving a large number of genes and variation in THz radiation characteristics and exposure duration are needed to generalize their findings. They also say that more direct experimental investigations of THz radiation’s ability to induce specific openings of the DNA double strand are needed to fully determine how THz radiation may work through DNA dynamics to influence cellular function.
The team led by Los Alamos National Lab worked in collaboration with the Center for Integrated Nanotechnologies, a US Department of Energy, Office of Basic Energy Sciences user facility at Los Alamos and Sandia National Laboratories, and with Harvard Medical School, and Beth Israel Deaconess Medical Center.
SOURCE: Biomedical Optics Express, “Non-thermal effects of terahertz radiation on gene expression in mouse stem cells http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-9-2679
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