Showing posts with label terahertz. Show all posts
Showing posts with label terahertz. Show all posts

Saturday, January 18, 2014

TERAHERTZ IMAGING: Terahertz parametric oscillator enables sensitive imaging




A narrowband terahertz parametric oscillator creates high-peak-power picosecond terahertz pulses that are suitable for active detection and thus the capturing of high-contrast, real-time images without the use of background-subtraction methods.

PATRICK TEKAVEC
The terahertz region of the electromagnetic spectrum (0.1 to 10 THz) is very attractive for nondestructive evaluation applications in defense, security, biomedical imaging, and monitoring of industrial processes. However, performance of terahertz imaging systems is limited by the lack of high-power sources and sensitive detectors in this spectral range. Here we present a novel, high-power terahertz source and propose an imaging method based on upconversion of terahertz waves to infrared (IR) light that offers an orders-of-magnitude increase in contrast over existing systems. The proposed imaging method mixes the terahertz signal with IR light to create an upconverted image that can be detected with commercially available IR cameras.
Microtech Instruments has recently developed a high-power terahertz source, called a terahertz parametric oscillator (TPO), based on difference-frequency generation inside of an optical parametric oscillator (OPO) pumped by a fiber laser (see http://bit.ly/19XjzPh). With a narrow bandwidth of less than 0.1 THz, the output can easily fit through the atmospheric transmission window at 1.5 THz, minimizing attenuation when propagated over large distances. With an average output power of greater than 300 μW, this makes it a good source for near-single-frequency imaging. The pulse duration of 6 ps also gives high peak powers of greater than 450 mW, which makes it a good source to drive nonlinear interactions.

FIGURE. A schematic diagram depicts nonlinear terahertz 2D imaging. A terahertz beam in the far field illuminates the object. A lens is used to image this onto a nonlinear crystal, where the terahertz image is mixed with an optical probe beam and converted to an optical image. The strong probe beam is blocked by a suitable filter, and the image formed by the nonlinear interaction is detected with an array detector.

Active vs. direct detection

There are two main methods to detect terahertz radiation in free space: direct detection with a Golay cell or bolometer, for example, and active detection where terahertz is mixed with an optical field, and an optical detector is used. Direct detectors tend to be slow and lack sensitivity, making them cumbersome for imaging applications. Active detection relies on a nonlinear process, where the terahertz beam is converted to an optical signal. The conversion efficiency of terahertz to optical depends on the peak powers used; thus, short pulses are desirable.
Electro-optic sampling is a well-established active-detection method, where broadband terahertz pulses are mixed with femtosecond optical pulses (probe pulses) in a suitable nonlinear crystal. The terahertz field induces a birefringence, and the change in polarization of the optical field is detected with a polarized oriented to block the probe pulse. In this way the entire terahertz field can be sampled by scanning the delay between terahertz and probe pulses, giving complete amplitude and phase information. This method has been used with a single-element detector with a pixel-by-pixel raster scan to obtain terahertz images. By illuminating the object in the far field as shown in the figure, a complete 2D image can be obtained with an optical-array detector.1
The quality of the image and speed at which it can be obtained depend of the power in the nonlinear signal and the amount that the probe beam can be attenuated. With broadband pulses, the incident terahertz power is low, and the use of a polarizer as filter won't remove the entire probe beam. This means that in general a weak signal is detected on top of strong background. While it is possible to use background-subtraction techniques to increase image quality, it is desirable to have the ratio of signal to background as high as possible.2 This can be expressed as a figure of merit: FOM = (signal power)/(attenuated probe power). The method we propose is to increase this figure of merit by increasing the power in the signal beam and increasing the probe beam attenuation.

Upconversion process

The nonlinear interaction that samples the terahertz beam can be thought of as an upconversion process, where the terahertz and probe beam interact to produce frequency sidebands. If ω0 is the center frequency of the optical beam and ωTHz is the frequency of the terahertz beam, sidebands are generated at ω0 + ωTHz and ω0 - ωTHz. When broadband pulses are used, the sidebands are overlapped with the probe beam, and polarization must be used to remove the background. However, in practice, there is often residual birefringence and scattering that degrade the actual blocking efficiency. With the use of narrowband fields and an appropriate notch filter, spectrally well-separated sidebands can be spectrally.
Upconversion detection has been done with continuous-wave terahertz beams and nanosecond optical pulses.3 However, the resulting signal is weak due to the low peak power in the terahertz beam and low duty cycle of the optical pulses. By using the TPO as a terahertz source, high peak powers from picosecond pulses give a high terahertz-to-optical conversion efficiency, while the narrow spectrum enables efficient removal of background. We expect up to 1 μW of optical power to be generated in the upconversion signal, and a figure of merit improvement of two to three orders of magnitude over existing methods. With an upconverted signal now much larger than the background, high-contrast, real-time images are expected to be obtained without the use of background-subtraction methods.
ACKNOWLEDGEMENT
The work for this is currently underway with the recently awarded Phase 1 SBIR from the National Science Foundation (SBIR IIP-1315916).
REFERENCES
1. Q. Wu et al., Appl. Phys. Lett., 69, 8, 1026 (1996).
2. Z. Jiang et al., Appl. Opt., 39, 17, 2982 (2000).
3. M. J. Khan et al., Opt. Lett., 32, 22, 3248-3250 (2007).
Patrick Tekavec is a research scientist at Microtech Instruments, Inc., 858 West Park Street, Eugene, OR 97401; e-mail: tekavec@mtinstruments.com; www.mtinstruments.com.

Friday, February 25, 2011

Terahertz development is receiving large financial support for expansion and commecialization

MY NOTE: THE REAL NEWS REGARDING TERAHERTZ TODAY, COMES FROM THE FINANCIAL WORLD. THE STORY POSTED LAST NIGHT ABOUT TERAVIEW LOOKING TO RAISE 2 MILLION POUNDS, AS CAPITAL TO GROW THEIR THz, DEVELOPMENTS WITH INTEL, IS FOLLOWED TODAY BY ADVANCED PHOTONIX"S (API), NEWS ARTICLE THAT THEY HAVE PLACED THE FINAL SHARES OF A $7 MILLION DOLLAR SHELF OFFERING TO EXPAND AND DEVELOP THEIR RESEARCH AND FACTORY SPACE FOR THz, AND HSOR EXPANSION.


ANN ARBOR, Mich.--(BUSINESS WIRE)-- Advanced Photonix, Inc. (NYSE-Amex: API) announced today that it entered into an underwriting agreement with B. Riley & Co., LLC, providing for the sale of 1,200,000 shares of its Class A Common Stock at a purchase price of $1.97 a share, less an underwriting discount of $0.1182 a share.


The shares of common stock are being sold pursuant to the Company’s registration statement on Form S-3 (File No. 333-171390), which was declared effective by the Securities and Exchange Commission on January 5, 2011.


Richard Kurtz, CEO of Advanced Photonix, Inc. stated "This final draw down of our existing shelf registration will be used for our general corporate purposes including (i) working capital needed to support the rapid growth of our HSOR products in foreign markets, (ii) accelerated development and marketing of Terahertz applications, (iii) capital expenditures needed to further automate our manufacturing processes, and increase our productivity."


A prospectus supplement relating to the offering will be filed with the SEC. Copies of the prospectus supplement and accompanying prospectus may be obtained at the SEC's website at http://www.sec.gov or directly from the Company by written request to Investor Relations c/o Richard Kurtz. This announcement shall not constitute an offer to sell or the solicitation of an offer to buy, nor will there be any sale of the shares referred to in this press release in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful.


About Advanced Photonix, Inc.


Advanced Photonix, Inc.® (NYSE-Amex: API) is a leading supplier with a broad offering of optoelectronic products to a global customer base. We provide optoelectronic solutions, high-speed optical receivers and terahertz instrumentation for telecom, homeland security, military, medical and industrial markets. With our patented technology and state-of-the-art manufacturing we offer industry leading performance, exceptional quality, and high value-added products to our OEM customer base. For more information visit us on the web at www.advancedphotonix.com.


The information contained herein includes forward looking statements that are based on assumptions that management believes to be reasonable but are subject to inherent uncertainties and risks including, but not limited to, unforeseen technological obstacles which may prevent or slow the development and/or manufacture of new products; potential problems with the integration of acquired companies and their technology and possible inability to achieve expected synergies; obstacles to successfully combining product offerings and lack of customer acceptance of such offerings; limited (or slower than anticipated) customer acceptance of new products which have been and are being developed by the Company; and a decline in the general demand for optoelectronic products. API-G

Thursday, February 24, 2011

TeraView cash call to fuel global growth after Intel alliance

Image representing Intel as depicted in CrunchBaseImage via CrunchBase


http://www.businessweekly.co.uk/index.php?option=com_content&view=article&id=38141:teraview-cash-call-to-fuel-global-growth-after-intel-alliance&catid=291:technology&Itemid=1036
TeraView in Cambridge is raising £2 million to exploit a game-changing opportunity in multi-billion dollar mobile phone and tablet personal computer markets identified through an alliance with Intel.
TeraView specialises in 3D imaging and spectroscopic systems that exploit the properties of terahertz technology.

The company is set to hire key sales staff in Cambridge and Asia and long-term will be opening global offices to leverage the opportunity created through the Intel collaboration on a new inspection tool for the semiconductor industry.

In an exclusive interview with Business Weekly, CEO Don Arnone revealed how Intel’s approach for a specific solution had acted as a catalyst for a twin-headed attack by TeraView on the semiconductor segment and also the solar cell inspection market, although that may be a longer-term play.

He expects the new paradigm to help TeraView double or even triple revenues in the not-too-distant future.

Arnone told me: “The new fundraising is a direct result of the Intel alliance. It’s great that such exciting opportunities have opened up as a direct result of a customer coming to us for a solution to a problem; it’s a whole new dynamic.

“Intel and ourselves co-developed a next generation high resolution terahertz time domain reflectometry unit designed for studying package interconnects. It answers the need in the mobile and tablet segments for more power and functionality within integrated circuits.

“The unit currently offers sub 10 micron resolution, which is an order of magnitude better than the current millimetre wave systems. Options exists to improve the resolution further. Customers want one micron or below. We’re working on it. There’s much more headroom in our technology development.

“Intel was an early identifier of the capabilities of Terahertz and built a roadmap around the new tool; now we are talking to non-Intel customers. There has been a lot of interest in taking the tool – notably from the Far East.

“We are in discussions with a lot of the major semiconductor players globally and are talking to existing and new investors to raise the capital to strengthen our technical and commercial teams in Cambridge as well as the far East and US.

“We have a product and now we need to improve our sales capabilities to maximise the opportunity. That applies here in Cambridge and also in Asia in the short term – further afield in the longer term.

“We have adopted an extremely focused model for growth. Taiwan represents the biggest single opportunity as it has the majority of companies involved in integrated circuit manufacture. Then we will target China, Korea and Japan – probably in that order.

“A few opportunities have presented themselves in different markets that we decided not to target because we didn’t want to scatter-gun.”

Still only around 20 people in Cambridge, TeraView clarly has the potential to double headcount in quickfire time. Its investment model is also interesting.

The company is in dialogue with with existing investors and new backers – but these are not just VCs. “We are also talking to companies and customers of ours who recognise the potential of this product. You’ve just seen Samsung set up a London office and it is no coincidence that a lot of big American technology players are in Cambridge and the UK looking at corporate venturing opportunities.

“There are a lot of US corporates out there at the moment with big cash stockpiles.”

Arnone said TeraView appreciated emerging in the commercial sunshine after a difficult transition since spinning out of Cambridge University.

He said: “It’s been difficult. But we have developed a core business that turns over good recurrent revenue and is growing at 10-15 per cent a year. Our commercial focus is good.”

TeraView’s imaging technology has also achieved success in analytics and defence markets. It could also lead to increased efficiency of controlled release pharmaceuticals.

One of its imaging machines is being used for ongoing research in the university’s Department of Chemical Engineering and Biotechnology.

Dr Axel Zeitler, a lecturer in the Department who focuses on terahertz spectroscopy and imaging, will use TeraView’s tablet imaging system to further his research in the area of terahertz radiation and how it can be used to develop better processes and products, with a particular interest in pharmaceutical manufacturing.

Terahertz radiation is the ‘last frontier’ of the electromagnetic spectrum, occupying frequencies between microwaves and infrared. The equipment developed by TeraView uses terahertz radiation to produce highly detailed three-dimensional images, which are useful across a wide range of fields, including the semiconductor, solar, intelligence and pharmaceutical industries.

In the pharmaceutical industry, terahertz radiation is used to produce highly detailed images of pills and capsules and provides clear advantages over existing methods, as x-ray and infrared frequently lack the sensitivity to produce the same quality of images without destroying the tablet itself.

The images produced using TeraView’s equipment enable researchers to detect minute cracks and defects present in the coating of the tablets, especially important in sustained or controlled release versions where a lack of uniformity in the coating can lead to serious problems in both safety and efficacy.

The method developed by TeraView is unique in that it can map both tablet coating thickness and density, which when measured together form a more accurate indication of a tablet’s dissolution characteristics.

TeraView is now active in 16 countries and sells equipment and expertise to more than 40 industrial users, academic institutions and government agencies, particularly in the United States, as well as partners in the pharmaceutical, security, semiconductor and solar industries.

It recently entered into a major collaboration with Ohio State University, assisting in the development of products and supplying equipment to the university’s researchers.

TeraView has also recently extended the technology and its equipment is now being sold to leading semiconductor companies as a vital part of the assembly and testing of advanced semiconductor chips.

TeraView was spun-out from Toshiba Research Europe in 2001 by Sir Michael Pepper, Emeritus Professor of Physics, and Dr Don Arnone to exploit the intellectual property and expertise developed in sourcing and detecting terahertz radiation, using innovative semiconductor technologies.

The company has an ongoing relationship with the University of Cambridge, in particular the Cavendish Laboratory, as well as with other University departments. 
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Wednesday, February 23, 2011

Enhancing Terahertz scanners using Compressive Sensing Technology



MY NOTE: THIS STORY CAUGHT MY EYE BECAUSE IT MENTIONS A NEW AGREEMENT SIGNED BY IQT, SOME OF YOU WILL REMEMBER ENTERED INTO AN AGREEMENT WITH ADVANCED PHOTONIX ON NOVEMBER 5TH, 2010, TO ENGINEER A LOW COST ANOMALY DEVICE USING THz, 

INVIEW TECHNOLOGY DOES NOT ACCESS THE SPECTRAL WAVELENGTH IN THE MANNER WE TYPICALLY DISCUSS HERE, BUT RATHER USES COMPRESSIVE SENSING TECHNOLOGY. ONE HAS TO WONDER IF IQT INTENDED TO SOMEHOW ENHANCE THE ANOMALY DETECTION DEVICE WITH COMPRESSIVE SENSING TECHNOLOGY. YOUR THOUGHTS AND COMMENTS APPRECIATED. 
LINK ON COMPRESSIVE SENSING:
http://www.wired.com/magazine/2010/02/ff_algorithm/
_____________________
InView Technology Corporation, a world-leading developer of innovative computational imaging products, today announced a strategic investment and development agreement from In-Q-Tel (IQT), the strategic investment firm that identifies innovative technology solutions to support the missions of the U.S. Intelligence Community.
InView's business is built on proprietary Compressive Sensing technology that allows high-performance cameras and hyperspectral imagers to be built using greatly simplified detector architectures. Compressive Sensing technology substitutes innovative math for complex electronic components, allowing cameras and hyperspectral imagers to be built at lower cost and with higher resolution. The technology is especially compelling for those wavelengths where it is difficult to build cost-effective, high-resolution focal plane arrays.
"InView has demonstrated innovative camera technologies," said Syd Ulvick, Vice President, Physical and Biological Technologies practice at IQT. "The unique computational imaging architecture provides tremendous opportunities to develop cutting-edge products."

"We are delighted to have IQT as a strategic investor and partner," said Bob Bridge, Founder and CEO of InView. "InView has an innovative technology platform that works across wavelengths including ultra violet, visual, infrared, and terahertz. We are pleased that working with IQT will open the door to opportunities to tailor our technology to meet the needs of the U.S. Intelligence Community."
About InView Technology Corporation:
InView Technology Corporation is a privately-held company headquartered in Austin, Texas. InView delivers high-performance cameras and hyper-spectral imagers using proprietary computational imaging technology that result in unmatched price-performance across the electromagnetic spectrum. You may find more information at www.InViewCorp.com.
About IQT:
In-Q-Tel is the strategic, not-for-profit investment firm that works to identify, adapt, and deliver innovative technology solutions to support the missions of the U.S. Intelligence Community. Launched in 1999 as a private, independent organization, IQT’s mission is to identify and partner with companies developing cutting-edge technologies that serve the national security interests of the United States. To learn more about IQT, visit www.iqt.org.  Read more


Read more: http://www.sunherald.com/2011/02/22/2882366/inview-technology-corporation.html#ixzz1EnKnzOKr



(FOR MORE ON COMPRESSIVE SENSING TECHNOLOGY, CHECK OUT A GREAT BLOG, I FOLLOW, AND WHICH LINKS TO THIS BLOG, NUIT-BLANCHE: http://nuit-blanche.blogspot.com/

Wednesday, February 16, 2011

New Terahertz Videos on the blog




The NJIT Highlanders logoImage via Wikipedia




A short note, to alert the readers, to two new videos, I've included on the blog, both of which are found below the posts. (I also include my personal commentary, which is based upon my opinion. As noted I am an investor in Advanced Photonix. I will correct any misstatement or misinformation upon
request).




 One new video,  is a video made by Dr. John Federici, at the New Jersey Institute of Technology. http://web.njit.edu/~federici/
There are several blog posts found on this site, which discuss the work being done at the NJIT. It's also worth pointing out that back in 2005,  NJIT purchased a T-Ray 2000, from Advanced Photonix to conduct it's research.

http://investor.advancedphotonix.com/releasedetail.cfm?releaseid=179765

I've also included a new video from TeraView, which discusses non-destructive industrial testing with THz, among other areas, it is using THz. In considering the various videos and Teraherz equipment, I am always struck by how large the TeraView system seems to be in comparison to the Advanced Photonix, T-Ray 4000. Some of you may also find this exchange with Rob Risser, API, CFO, to be of interest, from the API 2009 2nd Quarter conference call:

RANDY KNUDSEN: That's good. And I really appreciate that. Here's a question, and I don't know if this even makes sense, but let me ask it because the question is, is the TeraView system faster or slower? And I guess we really should be asking are we -- when we're talking about their pulse time domain, is theirs faster? Is that a sensible -- .?

ROB RISSER: No,
theirs is substantially slower.
RANDY KNUDSEN: Very good.

ROB RISSER: Yes. It is maybe in an order of magnitude slower.
http://goliath.ecnext.com/coms2/gi_0199-9576966/Q2-2009-Advanced-Photonix-Earnings.html

I have absolutely no way to know, if this remains true, (or was true), but I do note that API announced developments to the T-Ray 4000, after this call, indicating they had made it even 10 times faster than it was at that time.
http://terahertztechnology.blogspot.com/2009/08/t-4000-ten-times-faster.html

I'm happy to post a response, clarification or refutation, from the scientists at TeraView. I'm looking for commentary, and perhaps this will "stir" some interest.  Bottom line, I'm looking for ways to make comparisons in the various products being marketed, and  better understand the role companies will play in the  huge market which is developing. It's too bad there isn't some way of measuring or comparing the various systems on the market today, in one on one factory setting tests.

I'd also like to point out, that currently, API, is receiving significant funding from multiple US Goverment sources (Department of Homeland Security, IQT, Department of Transportation, & NASA) to make the 
T-Ray 4000, less expensive, even smaller and I believe, even a magnitude more powerful.

Bottomline, is that there is certainly plenty of  room in the virgin THz arena, for a number of companies to participate, and have great success. I certainly wish the folks at TeraView and at NJIT, good luck and future good fortune, in their Terahertz developments.
I hope you enjoy the new videos.
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POSTSCRIPT 2/17/11.  In regard to the additional Teraview video I have added, I wanted to share comments posted on Youtube regarding this video.
"The tablet is the blue object picked up by the robot and scanned infront of the THz emitter and detector which on the right of the movie. A laser guage is used to cacluate the size and shape of the tablet to perform the THz scan. For the last several years this equipment has been sold to and is being used by many of the major pharmaceutical companies for tablet inspection to investigate coating thickness and core properties. More information can be seen on Teraviews Website."


BECAUSE TERAVIEW IS NOT A PUBLICALLY TRADED COMPANY, THIS IS THE FIRST TIME I HAVE HEARD THEY ARE ACTUALLY SUPPLYING THz APPLICATIONS FOR COMMERCIAL USE BY THE PHARMACEUTICAL INDUSTRY. I'D LIKE TO KNOW A WHOLE LOT MORE. IN THE FINAL ANALYSIS, THE MORE APPLICATIONS ACTUALLY BEING PUT INTO USE, THE QUICKER THIS VIRGIN TECHNOLOGY WILL GAIN WIDESPREAD ACCEPTANCE.
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POSTSCRIPT 2/18/11.  I AM UNABLE TO FIND ANY CONFIRMATION THAT TERAVIEW IS USING IT'S THz APPLICATION, ON THE PRODUCTION LINE OF ANY MAJOR PHARMACEUTICAL COMPANY. SALES FOR LABORATORY USES HAVE OCCURRED, AND PERHAPS THOSE SALES WILL LEAD TO ACTUAL ONLINE QC INSPECTION. IF I AM MISTAKEN, PLEASE SHARE YOUR INFORMATION WITH ME
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Monday, February 14, 2011

Terahertz leader & innovator Advanced Photonix gives it's 3rd Quarter results

 Core Competencies
         

An exciting day, today listening and participating on the Advanced Photonix 3rd Quarter conference call. Since this is a Terahertz blog, let's start off, with the news on THz (The following are my notes and understanding of the conference call. An online recording of it, can be found here):


http://biz.yahoo.com/cc/3/120193.html

The first commercial sale has triggered widespread interest in the T-Ray 4000. Rick Kurtz, CEO, stated that "everyday" they are speaking to more and more potential customers, in a "wide range of industries". The alpha version of the product platform for use on the USAF, F-35 fighter jet has shipped with future sales, occurring, as the fighter gets into full production. The anomaly detection, device to be supplied to IQT, and the Dept of Homeland Security, is expected to ship in November for evaluation. Prior to that date the company anticipates the release of a new lower cost version of the T-Ray 4000, which should add to the attractiveness, to the customers  of the application.
Overall, the mood of both CEO Rick Kurtz, and CFO, Rob Risser was extremely positive. Overall the company predicts minimum future growth guidance at 35% annually.

The high speed optical receiver market continues to explode, because of huge demand all over the world for increased smart-phone, and video capacity. The company confirmed that each of the following major companies are HSOR customers, in either line-side, client side, metro, long haul, or ultra long haul HSOR, or in routers, switches and transport. (WDM):

  • Alcatel-Lucent;
  • Finisar;
  • Jdsu;
  • Nokia Siemens;
  • Opnext;
  • Ciena;
  • Oclaro;
  • Huawei;
  • Zte:

The company is making new inroads into the so-called,  "brick" industrial markets of  China, India, Russia, and Brazil, so expect more names to be added to this impressive list.

(Once again, these are my interpretations of today's Conference call. Listen to the actual call for your own confirmation, and please do your own due diligence before investing in anything.)
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Friday, February 11, 2011

Pharmaceutical Applications of Terahertz Spectroscopy and Imaging



MY NOTE: THIS IS OLD NEWS TO MOST OF YOU, BUT THz WILL CHANGE THE NATURE OF QUALITY CONTROL FOR MOST PHARMACEUTICAL COMPANIES IN THE NEXT FEW YEARS. THE ONLY REAL QUESTION IS HOW SOON?

Recent research has focused primarily on the systematic exploration of applications of terahertz radiation for the characterisation of pharmaceutical materials. Because the potential of the terahertz spectral range has only begun to be exploited recently, there is a lack of understanding of the interaction between terahertz light and organic molecular crystals, such as pharmaceutical drugs. Over the past three years we have been particularly interested in how most of the information in a terahertz spectrum reflects information directly originating from the crystal structure, and thus in physical rather than chemical properties of the materials.

Solid state characterisation

Drug polymorphism, where materials exhibit a different crystal structure while the chemical composition remains unchanged, is a very important phenomenon with a large number of economical and therapeutic implications for pharmaceutics. Familiar examples of polymorphic materials are diamond and graphite, which are both polymorphs of carbon. But while these polymorphs differ greatly, for instance in colour and hardness, others are not always that easy to distinguish. It is often difficult to differentiate between pharmaceutical polymorphs, where sometimes the only reliable technique is x-ray crystallography. However, not only is this method rather slow using a laboratory instrument but it is also potentially hazardous due to the ionising nature of x-ray radiation. We have found terahertz spectroscopy to be a technique with enormous potential, which could provide a rapid and intrinsically safe alternative for polymorph identification [1].


Examples of terahertz spectra of different pharmaceutically relevant polymorphs. Different forms of carbamazepine (top) and enalapril (bottom)
Five different polymorphs of sulfathiazole.

Quantitation

We have started to investigate the potential of terahertz radiation in comparison to other more established techniques, such as X-ray powder diffraction (XRPD), thermal analysis and different vibrational spectroscopy techniques in the infrared. We have looked into the quantification of small amounts of one polymorphic form mixed with another, as well as the determination of crystalline impurities in an amorphous matrix [2].


Quantification of physical mixtures of two polymorphic forms of carbamazepine by multivariate analysis (PLS) of their terahertz spectra.

Phase transitions

Terahertz spectroscopy is an excellent technique for this purpose; even though high accuracy and precision can be achieved using other techniques, the speed of terahertz measurements is unparalleled. Using the advantage of very fast measurements we characterised the transition from one polymorphic form to another in real time, [3]. We found that time-resolved terahertz spectroscopy allows to study in detail the mechanism and kinetics during a solid-state phase transition. We were able to confirm earlier findings of the mechanism of the particular phase transition for the material in question, which was thought to be a two-step process based on thermal analysis. This had never been observed in a spectroscopic measurement or quantified before [4].


Solid state conversion of carbamazepine form III to form I below the melting point of form III at 433 K


a) Kinetics of the solid state conversion of carbamazepine form III to form I. b) Amount of sublimated carbamazepine in the gas phase during the conversion process

Assignment of spectral features

To address the lack of theoretical understanding of terahertz spectra we have started to collaborate with Dr Graeme Day, a theoretical chemist from the Department of Chemistry at Cambridge University. In order to compare theory and experiment it is important to acquire spectral data at temperatures as low as possible, because nearly all computational methods available assume vibrational transitions from the ground state into the first excited state under harmonic conditions. We developed an experimental setup to measure terahertz spectra at 4 K and Dr Day developed a first approach to calculate the molecular vibrations at terahertz frequencies. The results of our collaboration were very promising, but as yet tentative [5]. We are currently trying to improve these calculations using first principles electronic structure calculations in crystalline environments. These more advanced calculations are computationally much more expensive, and our approach proved to be an excellent preliminary study to justify the resources required for such studies.

Further examples of pharmaceutical THz-TDS

Parallel to these investigations, we have looked at sulfathiazole. Sulfathiazole is one of the most complex polymorphic systems described in pharmaceutical literature and some of its forms are extremely difficult to differentiate. In conjunction with a novel high speed thermal analysis approach, we have been able to unambiguously identify the polymorphic forms and characterise the transformation processes between the forms [6]. Furthermore, we have investigated how low frequency Raman spectroscopy compares to terahertz spectroscopy over the same frequency range. The results indicated that Raman spectroscopy can be used equally well to distinguish the different polymorphic forms. However, we found that the measurement on the Raman system is far more elaborate, much slower to perform, and that the signal acquisition is often hindered by strong fluorescence.

With hydrate forms, we have applied terahertz spectroscopy to a further area of high practical significance. As hydration and dehydration processes are very common during the manufacture of pharmaceutical tablets, it is important to understand these phenomena on a molecular level prior to the design of the manufacturing process. The drug molecule can become less soluble or unstable due to hydration or dehydration: thus, once again, numerous implications arise on the therapeutic and processing level. Terahertz spectroscopy proved to be very well suited to study such systems [7, 8]. In contrast to other standard spectroscopic methods, terahertz spectroscopy has the additional advantage that evaporating hydrate water can be easily identified due to its very different spectrum compared to water still attached to the crystal. This is potentially very useful for the detailed mechanistic study of dehydration processes.

Terahertz Pulsed Imaging - coating characterisation in solid dosage forms

Besides its application for spectroscopy, terahertz radiation can also be used for structural imaging. We have been exploring potential applications of non-destructive terahertz imaging for different types of tablet coatings, controlled release tablets and capsules with a new instrumental setup that is designed specifically for the analysis of pharmaceutical dosage forms [9]. We evaluated the potential applications of an imaging instrument that is able to perform a fully automated measurement of a tablet of any shape. Using a robot arm, the whole surface of the tablet can be seamlessly scanned and a three-dimensional model of the internal structure of the tablet can be reconstructed from the terahertz data. The findings were validated by optical microscopy after preparing destructive cross-sections [10]. We have compared the coating quality parameters derived from the terahertz imaging experiment to the product performance in a dissolution study of different batches of tablets coated with a sustained release coating. While all tablets showed a similar weight gain, and thus appeared indistinguishable, the information from the terahertz imaging experiment allowed the measurement of coating thickness and density, which in turn allowed us to predict the performance of the tablets during dissolution testing [11].

Further Reading

[1] J.A. Zeitler et al., J. Pharm. Pharmacol. 59, 209 (2007).
[2] C.J. Strachan et al., J. Pharm. Sci. 94, 837 (2005).
[3] J.A. Zeitler et al., Thermochim. Acta 436, 71 (2005).
[4] J.A. Zeitler et al., ChemPhysChem 8, 1924 (2007).
[5] G.M. Day et al., J. Phys. Chem. B 110, 447 (2006).
[6] J.A. Zeitler et al., J. Pharm. Sci. 95, 2486 (2006).
[7] J.A. Zeitler et al., Int. J. Pharm. 334, 78 (2007).
[8] K. Kogermann et al., Appl. Spectrosc. in press (2007).
[9] J.A. Zeitler et al., J. Pharm. Sci. 96, 330 (2007).
[10] L. Ho et al., J. Control. Release 119, 253 (2007).
[11] L. Ho et al., J. Control. Release submitted (2007).
___
MY NOTE: PLEASE CHECK OUT THE FOLLOWING  API / PICOMETRIX, VIDEO FROM 2009:

http://tinyurl.com/ylb6e4s

Wednesday, February 2, 2011

TeraView product line

Teraview

MY NOTE: NICE TO GET A LOOK AT THE LATEST TERAVIEW PRODUCTS
http://www.teraview.com/terahertz/products/index.html

TeraView has created a number of products to help harness the unique properties of terahertz radiation.
By applying different software analysis packages, the same base technologies can be brought to bear to a wide range of applications.

THz Pulsed Imaging andSpectroscopy
THz Pulsed Imaging and Spectroscopy
EOTPR - Electro optical terahertz pulsed reflectometry 
CW400 – continuous wave terahertz spectrometer withimaging capabilities 
CW400
TeraView’s terahertz spectrometers utilize powerful, ultra-fast laser sources and semiconductor based detection systems to supply full access to the 0.06 – 4 THz (2 cm-1 - 120 cm-1) spectral region. 
These “plug and play” units are reliable, easy to use and flexible. They can be supplied with a wide range of ancillary spectroscopy and imaging modules that either fit directly onto the core unit or via a fibre optic feed. These modules can be provided at the time of purchase or added later as your needs change.
Extra modules include:
All our units come with a 12 month warranty and are supported on-site byTeraView’s global service team.
The unit is used to identify and quickly isolate faults on the interconnects of advanced packages, such as Flip Chip, Package on Package (PoP) and potentially Through-silicon vias(TSV) 

Key advantages of theEOTPR2000 include:

Rapid fault isolation—minutes rather than days

Identification of weak connections that may lead to  future faults 

Ability to isolate faults not previously seen with conventional TDR units

10 micron resolution

The CW Spectra 400 is the latest terahertz spectrometer from TeraView. It utilizes TeraView's proprietary GaAs-based photomixers and optical fibres to provide a robust and flexible, ready to use, turn-key system.
This standalone unit generates a continuous terahertz wave (CW-THz), tunable in frequency, which is emitted and detected via an appropriate set of proprietary, fibre-fed terahertz photomixers. By the addition of suitable supports, gantries or other units this CW Spectra 400 is capable of performing spectroscopy and imaging on a range of objects and materials.

Monday, January 31, 2011

Terahertz- New Video detaling the Advanced Photonix/Picometrix T-Ray 4000, on the blog

While I'm sure, you can't miss it, (See Video at the top of the page), I wanted to make a post regarding this new video. I received it this morning from Irl Duling at Picometrix, and I wanted to thank him for sharing this with us! It's very informative, and sheds a great deal of light, on the current state of the industry, which is going to be HUGE, in my estimation!
I also anticipate this will be the first, in a series of video's I have been promised from a variety of sources all relating to Terahertz development.

Wednesday, January 26, 2011

Taiwan makes breakthrough in optical light-field control including terahertz electronics

Taiwan makes breakthrough in optical light-field controlGraduate student Chan Han-sung (right) and postdoctoral researcher Hsieh Zhi-ming prepare to demonstrate equipment used for synthesizing and measuring optical field waveforms. (Courtesy of Andy Kung)

    Taiwanese researchers have made significant progress in creating an all-optical waveform synthesizer, which can be used to further development in nanonelectronics, nanomaterials and terahertz electronics.
    “The new method allows optical light fields to be controlled in a way similar to microwaves and radio waves,” said Andy Kung, research fellow at Academia Sinica’s Institute of Atomic and Molecular Sciences, Jan. 25.
    “In addition, it can help control chemical reactions through manipulating the movement of electrons in atoms and molecules.”
    Kung, who doubles as director of National Tsing Hua University’s Institute of Photonics Technologies, said scientists have long been attempting to develop an optical waveform synthesizer, or optical function generator, to serve as a vital piece of testing equipment in the advancement of various technologies.
    According to Kung, function generators–electronic equipment used to generate waveforms—utilize electrical circuits to produce these waveforms. “But they cannot be used for optics as electrons move more slowly than light,” he said.
    Academia Sinica’s research was published Jan. 20 on the website of leading international journal Science. (SB-JSM)

    Monday, January 24, 2011

    Terahertz -"Miscellaneous Musings"



                                                
                       (graphic taken from http://thznetwork.net/wp-content/galleries/THz-Images/images/thz4.jpg)


    No real news stories today regarding THz, so I thought I would cover some topics and thoughts, I haven't  covered before.

    1. PLEASE SHARE YOUR COMPANY NEWS AND/OR THz STORIES WITH ME
     I'm constantly writing to University professors, and company CEO's about THz, in an effort to find some new stories, and ideas relating to THz, development and commercialization. IF YOU HAVE INFORMATION REGARDING THz, AND WOULD LIKE TO SHARE IT WITH A BROADER AUDIENCE, PLEASE SEND IT TO ME. (My email address is knudson.randy@gmail.com)
    Dr. Daniel Mittleman, at Rice University, Dr. Irl Duling, at Picometrics/Advanced Photonix, and Dr. Thorsten Maly at Bridge12, have all been more than helpful in taking time to share with me, and in turn with you. As always, a big thanks to them. I'm waiting to hear from a number of other individuals, and let's hope they also want to bring greater attention, and awareness of THz to the world-at-large, by sharing with us.
    If anyone in the lay community runs across a newsworthy story, send it me. I'll be sure to give you credit for the find.

    2.QUESTIONS, QUESTIONS, QUESTIONS
    Back in October of 2008, TeraView announced it had entered into a contract with Goodrich to develop a chemical agent detection system.
    http://www.teraview.com/terahertz/news/id/1
     I followed up on this story line and in fact, Goodrich has developed it's own THz system, I assume using the TeraView technology.
     http://www.goodrich.com/Goodrich/Businesses/ISR-Systems/Products/Force-Protection-Products/Chemical-and-Biological-Protection
    It's my understanding this is a continuous wave system, but it's hard to find any indication that it gained any real market acceptance, but that's just my supposition. Is Goodrich actively engaged in further development of THz? I find nothing to indicate that they are, or they aren't. If anyone reading this knows, please share it with me.

    One smaller company, that has not been mentioned on this blog before, is a very interesting one to me. Zomega Terahertz Company,http://www.zomega-terahertz.com/products/index.html  has designed it's own time-domain, as well as a continuous wave THz systems.

     Many of us in the investment commmunity would like to have a better understanding of how each companies, relative systems, "stack-up" against, each other in terms of power, cost, and functionality. That is certainly one of the "goals" of this blog. 


     Here are the Zomega products:
    mini-Z 1000 THz Time Domain Spectrometer
    mini-Z THz Time Domain Spectrometers
    The most compact, fully integrated THz Time Domain Spectrometer, weighing in at less than 5 lbs with true turn-key operation. Produces and measures pulsed terahertz waves from 0.1 to 4.0 THz using time domain spectroscopy techniques in both transmission and reflection geometries with a waveform measurement of up to 20 Hz. Flexible enough for laboratory use and prototyping THz applications, but also designed to be integrated into larger systems requiring THz capabilities.

    mini-Z Product Brochure (PDF - 2.5MB) (Updated 1/23/09)
    >>mini-Z Identifcation Video (Windows Media) (Updated 10/28/09)
    >>mini-Z: On In 60 Seconds Video (Quicktime) (Updated 11/20/08)
    >>mini-Z Sorting Video (Quicktime) (Updated 9/12/08)

    Z-2 Time Domain Spectrometer
    Z-Series THz Time Domain Spectrometers
    Produces and measures pulsed terahertz waves from 0.1 to 3.5 THz using time domain spectroscopy techniques in both transmission and reflection geometries with a spectral resolution of 5 GHz. Flexible enough for laboratory use and prototyping THz applications, with easily extendable software provided through Labview.

    Z-2 Product Brochure (PDF - 2.1MB) (Updated 1/23/09)


    CW Systems
    C-Series THz Continuous Wave Systems
    Our line of integrated CW transmitters and receivers operating at 0.2, 0.4 or 0.6 THz for stand-off non-destructive testing applications. We offer the C-1LT series of CW systems which have a normal incidence angle of measurement with respect to the sample, and the C-2LT which offers both normal incidence and shallow-angle pitch-catch configurations (shown left). All systems are designed to be mounted on a scanning gantry for imaging applications (sold separately).

    C-1LT Series Product Brochure (PDF - 4.2MB)



    At this point in time, the only "metric" that I can find, to make an  assessment, about the relative viability of the various THz company products, is in actual contract sales, and once again, from the objective evidence, it appears, Advanced Photonix, holds a commanding lead over all of the other companies, as demonstrated by multiple stories on this blog.

    IF MY IMPRESSION, IS INCORRECT, THEN WOULD SOMEONE PLEASE SHARE SOME INFORMATION TO CHALLENGE OR REFUTE THIS PERCEPTION???

    Miscellaneous musings:
    • could the Bridge12 gyrotron be used to power a time-domain system?  (This may be a ridiculous question, but it's my understanding that the drawback or principal limitation, on current THz systems is lack of power, the gyrotron appears to meet this need.) Does the gyrotron, perform  spectroscopy, is another side of this inartful, question. Dr. Maly, care to comment?
    • when will the pharmaceutical community "wake-up", and begin using THz in it's production lines? The obvious cost savings in online detection of tainted or impure products, with resulting savings from litigation over the distribution of impure products is a no-brainer. I'm betting that the first placement of a THz unit on the factory floor occurs this calendar year. Any takers?
    • What are the chances that the Department of Homeland Security will seek the implementation of legislation, or perhaps an administrative rule banning the sale of nuclear gauges for industrial use? Use of the nuclear material by terrorists would be the obvious reason, and of course, now that Advanced Photonix has demonstrated that it's T-Ray Gauge is a viable, (and even superior replacement for nuclear gauges), perhaps it's time for HSD to make such a ban the law.
    That's all the I have today. Please feel free to post your comments and insights. 

    Wednesday, January 19, 2011

    JILA develops efficient source of terahertz radiation


    January 19, 2011New wave: JILA develops efficient source of terahertz radiation
    JILA instrument for generating terahertz radiation. Ultrafast pulses of near-infrared laser light enter through the lens at left, striking a semiconductor wafer studded with electrodes (transparent square barely visible under the white box connected to orange wires) bathed in an oscillating electric field. The light dislodges electrons, which accelerate in the electric field and emit waves of terahertz radiation. At right is a close-up of the electron source. Credit: Zhang/JILA
    (PhysOrg.com) -- JILA researchers have developed a laser-based source of terahertz radiation that is unusually efficient and less prone to damage than similar systems. The technology might be useful in applications such as detecting trace gases or imaging weapons in security screening.


    JILA is a joint institute of the National Institute of Standards and Technology (NIST) and the University of Colorado at Boulder.
    Terahertz radiation—which falls between the radio and optical bands of the electromagnetic spectrum—penetrates materials such as clothing and plastic but can be used to detect many substances that have unique absorption characteristics at these wavelengths. Terahertz systems are challenging to build because they require a blend of electronic and optical methods.
    The JILA technology, described in Optics Letters, is a new twist on a common terahertz source, a  surface patterned with metal electrodes and excited by ultrafast laser pulses. An  is applied across the semiconductor while near-infrared pulses lasting about 70 femtoseconds (quadrillionths of a second), produced 89 million times per second, dislodge electrons from the semiconductor. The electrons accelerate in the electric field and emit waves of terahertz radiation.
    The JILA innovations eliminate two known problems with these devices. Adding a layer of silicon oxide insulation between the gallium arsenide semiconductor and the gold electrodes prevents electrons from becoming trapped in semiconductor crystal defects and producing spikes in the electric field. Making the electric field oscillate rapidly by applying a radiofrequency signal ensures that electrons generated by the light cannot react quickly enough to cancel the electric field.
    The result is a uniform electric field over a large area, enabling the use of a large laser beam spot size and enhancing system efficiency. Significantly, users can boost terahertz power by raising the optical power without damaging the semiconductor. Sample damage was common with previous systems, even at low power. Among other advantages, the new technique does not require a microscopically patterned sample or high-voltage electronics. The system produces a peak terahertz field (20 volts per centimeter for an input power of 160 milliwatts) comparable to that of other methods.
    While there are a number of different ways to generate terahertz radiation, systems using ultrafast lasers and semiconductors are commercially important because they offer an unusual combination of broad frequency range, high frequencies, and high intensity output.
    NIST has applied for a provisional patent on the new technology. The system currently uses a large laser based on a titanium-doped sapphire crystal but could be made more compact by use of a different semiconductor and a smaller fiber laser, says senior author Steven Cundiff, a NIST physicist.
    More information: H. Zhang J.K. Wahlstrand, S.B. Choi and S.T. Cundiff. Contactless photoconductive terahertz generation. Optics Letters, Jan. 15, 2011.