Abstract-Research progress in the effects of terahertz waves on biomacromolecules

 

Liu Sun, Li Zhao,  Rui-Yun Peng, 

https://link.springer.com/article/10.1186/s40779-021-00321-8

With the rapid development of terahertz technologies, basic research and applications of terahertz waves in biomedicine have attracted increasing attention. The rotation and vibrational energy levels of biomacromolecules fall in the energy range of terahertz waves; thus, terahertz waves might interact with biomacromolecules. Therefore, terahertz waves have been widely applied to explore features of the terahertz spectrum of biomacromolecules. However, the effects of terahertz waves on biomacromolecules are largely unexplored. Although some progress has been reported, there are still numerous technical barriers to clarifying the relation between terahertz waves and biomacromolecules and to realizing the accurate regulation of biological macromolecules by terahertz waves. Therefore, further investigations should be conducted in the future. In this paper, we reviewed terahertz waves and their biomedical research advantages, applications of terahertz waves on biomacromolecules and the effects of terahertz waves on biomacromolecules. These findings will provide novel ideas and methods for the research and application of terahertz waves in the biomedical field.

Abstract-Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions

Sheng Zhi Tan, Peng Cheng Tan , Lan Qing Luo , Yun Liang Chi , Zi Long Yang , Xue Long Zhao , Li Zhao, Ji Dong, Jing Zhang, , Bin Wei Yao, Xin Ping Xu, Guang Tian , Jian Kui Chen, Hui Wang, Rui Yun Peng,

http://www.besjournal.com/en/article/doi/10.3967/bes2019.094

Objective: This study aimed to explore the potential effects of terahertz (THz) waves on primary cultured neurons from 4 rat brain regions (hippocampus, cerebral cortex, cerebellum, and brainstem) and 3 kinds of neuron-like cells (MN9D, PC12, and HT22 cells) under nonthermal conditions.

Methods: THz waves with an output power of 50 (0.16 THz) and 10 (0.17 THz) mW with exposure times of 6 and 60 min were used in this study. Analysis of temperature change, neurite growth, cell membrane roughness, micromorphology, neurotransmitters and synaptic-related proteins (SYN and PSD95) was used to evaluate the potential effects.

Results: Temperature increase caused by the THz wave was negligible. THz waves induced significant neurotransmitter changes in primary hippocampal, cerebellar, and brainstem neurons and in MN9D and PC12 cells. THz wave downregulated SYN expression in primary hippocampal neurons and downregulated PSD95 expression in primary cortical neurons.

Conclusion: Different types of cells responded differently after THz wave exposure, and primary hippocampal and cortical neurons and MN9D cells were relatively sensitive to the THz waves. The biological effects were positively correlated with the exposure time of the THz waves.

Copyright © 2019 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

Abstract-132-Gb/s Photonics-Aided Single-Carrier Wireless Terahertz-Wave Signal Transmission at 450GHz Enabled by 64QAM Modulation and Probabilistic Shaping

Xinying Li, Jianjun Yu, Li Zhao, Wen Zhou, Kaihui Wang, Miao Kong, Gee-Kung Chang, Ying Zhang, Xiaolong Pan, and Xiangjun Xin

https://www.osapublishing.org/abstract.cfm?uri=OFC-2019-M4F.4

We experimentally demonstrate 132-Gb/s (12-Gbaud) photonics-aided single-carrier PDM-64QAM-PS5.5 THz-wave signal transmission at 450GHz over 20-km fiber-optics and 1.8-m wireless distance with BER under 4×10−2. The employment of probabilistic-constellation-shaping significantly improves transmission capacity and system performance.

© 2019 The Author(s)

Abstract- ROF-OFDM system within terahertz-wave frequency range from 350GHz to 510GHz

Mingming Zhao, Kaihui Wang, Jimmy Yu, Can Wang, Jiangnan Xiao, Li Zhao, Miao Kong, Jianjun Yu

https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10946/109460E/ROF-OFDM-system-within-terahertz-wave-frequency-range-from-350GHz/10.1117/12.2513693.short?SSO=1

We experimentally demonstrate a photonics-based radio-over-fiber orthogonal-frequency-division-multiplexing (ROFOFDM) system located within the terahertz-wave (THz-wave) frequency range from 350GHz to 510GHz. In our demonstrated system, 4.46-GHz-bandwidth OFDM quadrature-phases-shift-keying (OFDM-QPSK) THz-wave signal within the frequency range from 350GHz to 510GHz, can be generated and delivered over 2.5-inch wireless transmission distance, with a bit-error ratio (BER) under the hard-decision forward-error-correction (HD-FEC) threshold of 3.8×10-3. In our demonstrated system, 4.46-GHz-bandwidth OFDM-QPSK THz-wave signal at 450GHz is delivered over up to 35-km fiber transmission distance and 2.5-inch wireless transmission distance, with a BER of 3.8×10-3.

https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10946/109460E/ROF-OFDM-system-within-terahertz-wave-frequency-range-from-350GHz/10.1117/12.2513693.short?SSO=1

Abstract-Advances in the biological effects of terahertz wave radiation

Li Zhao, Yan-Hui Hao and Rui-Yun Peng^*
http://www.mmrjournal.org/content/1/1/26/abstract

The terahertz (THz) band lies between microwave and infrared rays in wavelength and consists of non-ionizing radiation. Both domestic and foreign research institutions, including the army, have attached considerable importance to the research and development of THz technology because this radiation exhibits both photon-like and electron-like properties, which grant it considerable application value and potential. With the rapid development of THz technology and related applications, studies of the biological effects of THz radiation have become a major focus in the field of life sciences. Research in this field has only just begun, both at home and abroad. In this paper, research progress with respect to THz radiation, including its biological effects, mechanisms and methods of protection, will be reviewed.