Abstract-Heating system of pellet samples integrated with terahertz spectrometer

Sterczewski LA1, Grzelczak MP1, Plinski EF1.

http://www.ncbi.nlm.nih.gov/pubmed/26827308

This article describes automation of temperature-dependent terahertz spectroscopic experiments. The proposed dual-heater temperature controller based on a cascade proportional-integral-derivative algorithm provides smooth temperature changes in the polyethylene-based pharmaceutical pellet samples. The device has been integrated with a terahertz time-domain spectrometer. Thermodynamic experiments can now be performed without any probe inserted into the measured sample. Selected results of temperature-induced evolution in terahertz spectra are presented.

Abstract-Bayesian separation algorithm of THz spectral sources applied to D-glucose monohydrate dehydration kinetics

• L.A. Sterczewski^, , 
• M.P. Grzelczak, 
• K. Nowak, 
• B. Szlachetko, 
• E.F. Plinski

http://www.sciencedirect.com/science/article/pii/S0009261415008829

An estimation of the dehydration kinetics of monohydrated D-glucose with the use of the Bayesian spectral source separation algorithm is described. The dehydration experiment was probed with the terahertz time domain spectroscopy (THz-TDS). Contrary to the widely used peak-area method, our approach to the quantitative analysis takes into account the full spectral information. The obtained concentration profiles at different temperatures were processed in order to measure the kinetics of the dehydration process. Our investigation shows that the proposed method may be used to estimate the evolution of concentration despite the overlapping peaks and multiple spectral sources in the observed spectra.

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Graphical abstract