Showing posts with label DNA methylation. Show all posts
Showing posts with label DNA methylation. Show all posts

Friday, May 1, 2020

Abstract-Toward cancer treatment using terahertz radiation: demethylation of cancer cells


Joo-Hiuk Son; Hwayeong Cheon,

https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11390/1139002/Toward-cancer-treatment-using-terahertz-radiation--demethylation-of-cancer/10.1117/12.2557655.short

Carcinogenesis involves DNA methylation, a primary alteration in DNA, in the development of cancer before genetic mutation. Because abnormal DNA methylation is found in most cancer cells, the assessment and manipulation of DNA methylation using terahertz radiation can be a novel optical method to detect and control cancer. By directly observing the methylation via terahertz spectroscopy at approximately 1.65 THz, this epigenetic chemical change can be manipulated to the state of demethylation using high-power terahertz radiation. Demethylation of cancer DNA is a key issue in epigenetic cancer therapy, and our results may lead to the treatment of cancer using electromagnetic waves.

Monday, November 12, 2018

Abstract-Toward Cancer Treatment Using Terahertz Radiation: Demethylation of Cancer DNA


Joo-Hiuk Son, Hwayeong Cheon

https://ieeexplore.ieee.org/document/8510290

Carcinogenesis involves DNA methylation which is a primary alteration in DNA in the development of cancer occurring before genetic mutation. Because the abnormal DNA methylation is found in most of cancer cells, the detection and manipulation of DNA methylation using terahertz radiation can be a novel pioneering method in cancer study. The DNA methylation has been directly observed by terahertz spectroscopy at around 1.65 THz and this epigenetic chemical change could be manipulated to the state of demethylation using a high-power terahertz radiation. Demethylation of cancer DNA is a key problem in epigenetic cancer therapy and our results may lead to the treatment of cancer in early stage.