Abstract-Quantify Glucose Level in Freshly Diabetic’s Blood by Terahertz Time-Domain Spectroscopy

Hua Chen, Xiaofeng Chen, Shihua Ma, Xiumei Wu, Wenxing Yang, Weifeng Zhang, Xiao Li

https://link.springer.com/article/10.1007/s10762-017-0462-2

We demonstrate the capability of terahertz (THz) time-domain spectroscopy (TDS) to quantify glucose level in ex vivo freshly diabetic’s blood. By investigating the THz spectra of different human blood, we find out THz absorption coefficients reflect a high sensitivity to the glucose level in blood. With a quantitative analysis of 70 patients, we demonstrate that the THz absorption coefficients and the blood glucose levels perform a linear relationship. A comparative experiment between THz measurement and glucometers is also conducted with another 20 blood samples, and the results confirm that the relative error is as less as 15%. Our ex vivo human blood study indicates that THz technique has great potential application to diagnose blood glucose level in clinical practice.