Abstract-Non-destructive Determination of Disintegration Time and Dissolution in Immediate Release Tablets by Terahertz Transmission Measurements

Daniel Markl, Johanna Sauerwein, Daniel J. Goodwin, Sander van den Ban, J. Axel Zeitler

http://link.springer.com/article/10.1007/s11095-017-2108-4

The aim of this study was to establish the suitability of terahertz (THz) transmission measurements to accurately measure and predict the critical quality attributes of disintegration time and the amount of active pharmaceutical ingredient (API) dissolved after 15, 20 and 25 min for commercial tablets processed at production scale.