Yi Zou, Qiao Liu, Xia Yang, Hua-Chuan Huang, Jiang Li, Liang-Hui Du, Ze-Ren Li, Jian-Heng Zhao, and Li-Guo Zhu
https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-1-14&origin=search
We demonstrated that attenuated total reflectance terahertz time-domain spectroscopy (ATR THz-TDS) is able to monitor oxidative stress response of living human cells, which is proven in this work that it is an efficient non-invasive, label-free, real-time and in situ monitoring of cell death. Furthermore, the dielectric constant and dielectric loss of cultured living human breast epithelial cells, and along with their evolution under oxidative stress response induced by high concentration of H2O2, were quantitatively determined in the work. Our observation and results were finally confirmed using standard fluorescence-labeled flow cytometry measurements and visible fluorescence imaging.
© 2017 Optical Society of America under the terms of the OSA Open Access Publishing
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